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The endless frustrations of the SARS-CoV-2 crisis and pandemic response has led some to push back denying existence of the virus altogether.  
Laboratory methods in virology are well accepted and utilize a series of experiments to demonstrate cellular invasion, replication, transfer and repeated infection.  Whole genomic sequencing has aided in identification of variants and subvariants and helped greatly in forecasting what is coming next.  The CDC Nowcast system is an excellent application of targeted sequencing of viral samples.[i]
Nonetheless, some have said if SARS-CoV-2 cannot be cultured like a bacteria and "isolated" then it does not exist.  I have always responded that the principles of laboratory virology, sequencing, and the mass production of viruses such as that done by the Max Planck Institute for Dynamics of Complex Technical Systems are concrete processes that rely on the presence of the virus.[ii]...